Scientific breakthroughs are changing what may be possible in sickle cell. But reaching the breakthrough is not the end of the story. Progress also depends on how advances are translated into lifelong care, stronger evidence, earlier intervention and better everyday lives.

This year’s Top 80 recognises the advocates, healthcare leaders, researchers and innovators carrying that work forward. Their contributions extend from advancing new therapies and scientific understanding to improving early diagnosis, monitoring organ health, managing chronic symptoms and strengthening access to specialist support.

The 2027 publication looks beyond individual breakthroughs to consider what progress must become next. It explores the growing role of personalised medicine, biomarkers, imaging, digital monitoring and patient reported outcomes in understanding how sickle cell disorder changes over time. It also highlights the people connecting research with implementation, ensuring that screening leads to continued care and that lived experience helps define the outcomes that matter.

Across research, healthcare and advocacy, those featured demonstrate that progress does not follow a single pathway. It is shaped by scientific discovery, sustained clinical leadership, stronger health systems, community based support and the voices of people living with sickle cell disorder.

We extend our sincere congratulations and thanks to everyone recognised in the 2027 Top 80. Your work is helping move the field beyond what is scientifically possible towards care that is more proactive, personalised, equitable and responsive throughout life.

Explore the full Top 80 Most Influential Advocates and People in Sickle Cell Research 2027.

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